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Article

Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility.

Stroke - 1 Jul 2002

Koistinaho Milla, Kettunen Mikko I, Holtzman David M, Kauppinen Risto A, Higgins Linda S, Koistinaho Jari

Abstract excerpt

BACKGROUND AND PURPOSE: Epidemiological findings and experimental data on transgenic mice show that Alzheimer's disease-related changes render the brain more susceptible to ischemic damage. We studied whether the previously observed vulnerability in mice overexpressing the 751-amino-acid isoform of human amyloid precursor protein (APP751) is regulated by human apolipoprotein E (apoE) alleles, which determine the...

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Source

Identifiers

PMID: 12105373
DOI: 10.1161/01.str.0000020124.61998.bc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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