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Article

Compromised hemodynamic response in amyloid precursor protein transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2002

Mueggler Thomas, Sturchler-Pierrat Christine, Baumann Diana, Rausch Martin, Staufenbiel Matthias, Rudin Markus

Abstract excerpt

APP23 transgenic mice overexpressing amyloid precursor protein (APP751) reproduce neuropathological changes associated with Alzheimer's disease such as high levels of amyloid plaques, cerebral amyloid angiopathy, and associated vascular pathologies. Functional magnetic resonance imaging (fMRI) was applied to characterize brain functionality in these mice through global pharmacological stimulation. The cerebral...

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Identifiers

PMID: 12177216
PMCID: PMC6757895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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