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Article

Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice.

The Journal of biological chemistry - 19 Nov 2010

Lefterov Iliya, Fitz Nicholas F, Cronican Andrea A, Fogg Allison, Lefterov Preslav, Kodali Ravindra, Wetzel Ronald, Koldamova Radosveta

Abstract excerpt

A hallmark of Alzheimer disease (AD) is the deposition of amyloid β (Aβ) in brain parenchyma and cerebral blood vessels, accompanied by cognitive decline. Previously, we showed that human apolipoprotein A-I (apoA-I) decreases Aβ(40) aggregation and toxicity. Here we demonstrate that apoA-I in lipidated or non-lipidated form prevents the formation of high molecular weight aggregates of Aβ(42) and decreases Aβ(42)...

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Source

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Identifiers

PMID: 20739292
DOI: 10.1074/jbc.M110.127738
PMCID: PMC2978623

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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