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Article

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.

Human molecular genetics - 1 Oct 1997

Carlson G A, Borchelt D R, Dake A, Turner S, Danielson V, Coffin J D, Eckman C, Meiners J, Nilsen S P, Younkin S G, Hsiao K K

Abstract excerpt

Overexpression of Alzheimer amyloid precursor protein (APP) produces dramatically different phenotypes in transgenic mice depending on the genetic background. For example, concentrations of APP that produce amyloid plaques in outbred transgenic lines are lethal for inbred FVB/N or C57BL/6J mice....

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Source

Identifiers

PMID: 9302276
DOI: 10.1093/hmg/6.11.1951

Genes

APP
FGF2
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9302276-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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