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Article

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.

Neuron - 21 Jul 2005

McGowan Eileen, Pickford Fiona, Kim Jungsu, Onstead Luisa, Eriksen Jason, Yu Cindy, Skipper Lisa, Murphy M Paul, Beard Jenny, Das Pritam, Jansen Karen, DeLucia Michael, Lin Wen-Lang, Dolios Georgia, Wang Rong, Eckman Christopher B, Dickson Dennis W, Hutton Mike, Hardy John, Golde Todd

Abstract excerpt

Considerable circumstantial evidence suggests that Abeta42 is the initiating molecule in Alzheimer's disease (AD) pathogenesis. However, the absolute requirement for Abeta42 for amyloid deposition has never been demonstrated in vivo. We have addressed this by developing transgenic models that express Abeta1-40 or Abeta1-42 in the absence of human amyloid beta protein precursor (APP) overexpression. Mice...

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Source

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Identifiers

PMID: 16039562
DOI: 10.1016/j.neuron.2005.06.030
PMCID: PMC1373682

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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