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Mechanisms of Cerebrovascular Amyloid Deposition: Lessons from Mouse Models

1 Apr 2000

Abstract excerpt

Cerebrovascular deposition of amyloid is a frequent observation in Alzheimer's disease patients. It can also be detected sporadically in normal aged individuals and is further found in familial diseases linked to specific gene mutations. The source and mechanism of this pathology are still unknown. It has been suggested that amyloidogenic proteins are derived from blood, the vessel wall itself, or from the...

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PMID: 10818520
DOI: 10.1111/j.1749-6632.2000.tb06381.x

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