Article
Application of the p53 gene mutation pattern for differential diagnosis of primary versus metastatic lung carcinomas.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 1993
Noguchi M, Maezawa N, Nakanishi Y, Matsuno Y, Shimosato Y, Hirohashi S
Abstract excerpt
The p53 gene mutation pattern was used as a diagnostic marker of multiple and second primary lung carcinomas. Nine cases of multiple carcinoma, which were suspected clinicopathologically to be double or triple primary carcinomas, were examined for p53 protein expression by immunohistochemistry an...
Topics
- Base Sequence
- DNA, Neoplasm
- DNA, Single-Stranded
- Diagnosis, Differential
- Genes, p53
- Humans
- Immunoenzyme Techniques
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Neoplasms, Multiple Primary
- Neoplasms, Second Primary
- Polymerase Chain Reaction
- Polymorphism, Genetic