Article
A multiple primary carcinoma consisting of leukoplakia and SCC: a case report with p53 mutation analysis.
Anticancer research - 1 Nov 2010
Hassan Nur Mohammad Monsur, Tada Mitsuhiro, Shindoh Masanobu, Hamada Jun-Ichi, Kashiwazaki Haruhiko, Shimo Tsuyoshi, Ashikaga Yuichi, Yamazaki Yutaka, Sasaki Akira, Moriuchi Tetsuya, Inoue Nobuo
Abstract excerpt
Patients with an oral squamous cell carcinoma (OSCC) often develop multiple malignant lesions. This report examined whether individual tumours developed in a patient show the same genetic alteration, such as p53 mutations. This case study describes three SCCs and three leukoplakias which developed simultaneously in a single 67-year-old Japanese man. A p53 mutation was detected in two of the three SCCs and one of...
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