Article
p53 Mutations in carcinoma of the esophagus and gastroesophageal junction.
Cancer investigation - 1 Jan 2009
Sengpiel C, König I R, Rades D, Noack F, Duchrow M, Schild S E, Ludwig D, Homann N
Abstract excerpt
BACKGROUND: Recent studies suggested p53 mutations as a prognostic factor. Tumors of the esophagus and gastroesophageal (GE) junction show raising incidence with a general poor prognosis. METHODS: p53 Mutational spectra in 103 patients (68 squamous cell carcinoma/SCC and 35 adenocarcinoma/AC) were compared to clinical and pathologic data. RESULTS AND CONCLUSIONS: p53 Mutations were found in 26 of 68 SSC (38.2%)...
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