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Article

Multiple primary tumors of the upper aerodigestive tract: is there a role for constitutional mutations in the p53 gene?

International journal of cancer - 19 Jul 1999

Gallo O, Sardi I, Pepe G, Franchi A, Attanasio M, Giusti B, Bocciolini C, Abbate R

Abstract excerpt

Head-and-neck cancer (HNC) patients have a high risk of developing second primary tumors of the upper aerodigestive tract, the main cause of death. Although the roles of tobacco and diet in multiple head-and-neck carcinogenesis have been thoroughly investigated, little is known about individual genetic susceptibility factors involved in this process. Genomic instability, reflecting the propensity and the...

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Source

Identifiers

PMID: 10389749
DOI: 10.1002/(sici)1097-0215(19990719)82:2<180::aid-ijc5>3.0.co;2-p

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CGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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