Article
Counteraction by MutT protein of transcriptional errors caused by oxidative damage.
Science (New York, N.Y.) - 3 Oct 1997
Taddei F, Hayakawa H, Bouton M, Cirinesi A, Matic I, Sekiguchi M, Radman M
Abstract excerpt
Oxidized guanine (8-oxo-7,8-dihydroguanine; 8-oxo-G) is a potent mutagen because of its ambiguous pairing with cytosine and adenine. The Escherichia coli MutT protein specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-rGTP), which a...
Topics
- Aerobiosis
- Anaerobiosis
- Bacterial Proteins
- Codon
- Deoxyguanine Nucleotides
- Escherichia coli
- Escherichia coli Proteins
- Guanosine Triphosphate
- Hydrolysis
- Lac Operon
- Mutation
- Oxidation-Reduction
- Phosphoric Monoester Hydrolases
- Point Mutation
- Pyrophosphatases
- RNA, Bacterial
- RNA, Messenger
- Templates, Genetic