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Article

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.

Science (New York, N.Y.) - 3 Oct 1997

Taddei F, Hayakawa H, Bouton M, Cirinesi A, Matic I, Sekiguchi M, Radman M

Abstract excerpt

Oxidized guanine (8-oxo-7,8-dihydroguanine; 8-oxo-G) is a potent mutagen because of its ambiguous pairing with cytosine and adenine. The Escherichia coli MutT protein specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-rGTP), which are otherwise incorporated in DNA and RNA opposite template A. In vivo, this cleaning of the nucleotide pools decreases...

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PMID: 9311918
DOI: 10.1126/science.278.5335.128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Counteraction by MutT protein of transcriptional errors caused by oxidative damage.PMID 9311918Read ↗

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.Semantic proximity Read ↗

The role of the mutT gene of Escherichia coli in maintaining replication fidelitySemantic proximity Read ↗

Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity.Semantic proximity Read ↗

Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains.Semantic proximity Read ↗

A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage.Semantic proximity Read ↗

The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.Semantic proximity Read ↗

Thermostable repair enzyme for oxidative DNA damage from extremely thermophilic bacterium, Thermus thermophilus HB8.Semantic proximity Read ↗

A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.Semantic proximity Read ↗

Increased A:T-->C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: direct evidence for MutT involvement in the prevention of mutations by oxidized dGTP.Semantic proximity Read ↗

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Genome-wide surveillance of transcription errors in response to genotoxic stress.Semantic proximity Read ↗

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