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Article

Inactivation of the DNA repair genes mutS, mutL or the anti-recombination gene mutS2 leads to activation of vitamin B1 biosynthesis genes.

PloS one - 28 Apr 2011

Fukui Kenji, Wakamatsu Taisuke, Agari Yoshihiro, Masui Ryoji, Kuramitsu Seiki

Abstract excerpt

Oxidative stress generates harmful reactive oxygen species (ROS) that attack biomolecules including DNA. In living cells, there are several mechanisms for detoxifying ROS and repairing oxidatively-damaged DNA. In this study, transcriptomic analyses clarified that disruption of DNA repair genes mutS and mutL, or the anti-recombination gene mutS2, in Thermus thermophilus HB8, induces the biosynthesis pathway for...

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Identifiers

PMID: 21552516
DOI: 10.1371/journal.pone.0019053
PMCID: PMC3084264

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of the DNA repair genes mutS, mutL or the anti-recombination gene mutS2 leads to activation of vitamin B1 biosynthesis genes.PMID 21552516Read ↗

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