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Article

A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage.

Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2020

Dupuy Pierre, Howlader Mir, Glickman Michael S

Abstract excerpt

Oxidative damage to DNA is a threat to the genomic integrity and coding accuracy of the chromosomes of all living organisms. Guanine is particularly susceptible to oxidation, and 8-oxo-dG (OG), when produced in situ or incorporated by DNA polymerases, is highly mutagenic due to mispairing with adenine. In many bacteria, defense against OG depends on MutT enzymes, which sanitize OG in the nucleotide pool, and the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32727901
DOI: 10.1073/pnas.2006792117
PMCID: PMC7431094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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