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Article

The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.

Journal of bacteriology - 1 Oct 2007

Rotman Ella, Kuzminov Andrei

Abstract excerpt

Nucleotide pool sanitizing enzymes Dut (dUTPase), RdgB (dITPase), and MutT (8-oxo-dGTPase) of Escherichia coli hydrolyze noncanonical DNA precursors to prevent incorporation of base analogs into DNA. Previous studies reported dramatic AT-->CG mutagenesis in mutT mutants, suggesting a considerable density of 8-oxo-G in DNA that should cause frequent excision and chromosomal fragmentation, irreparable in the...

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Identifiers

PMID: 17616589
DOI: 10.1128/JB.00776-07
PMCID: PMC2045204

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The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.PMID 17616589Read ↗

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A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage.Semantic proximity Read ↗

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.Semantic proximity Read ↗

A novel mutator of Escherichia coli carrying a defect in the dgt gene, encoding a dGTP triphosphohydrolase.Semantic proximity Read ↗

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.Semantic proximity Read ↗

Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing.Semantic proximity Read ↗

Plasmid expression of mutS, -L and/or -H gene in Escherichia coli dam cells results in strains that display reduced mutation frequency.Semantic proximity Read ↗

Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity.Semantic proximity Read ↗

Mutations in the mutY gene of Escherichia coli enhance the frequency of targeted G:C-->T:a transversions induced by a single 8-oxoguanine residue in single-stranded DNA.Semantic proximity Read ↗

SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and RepairSemantic proximity Read ↗

Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine:guanine mispair to prevent spontaneous G:C-->C:G transversions.Semantic proximity Read ↗

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