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Article

A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.

EMBO reports - 1 May 2003

Ishibashi Toru, Hayakawa Hiroshi, Sekiguchi Mutsuo

Abstract excerpt

MutT-related proteins, including the Escherichia coli MutT and human MutT homologue 1 (MTH1) proteins, degrade 8-oxo- 7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP) to a monophosphate, thereby preventing mutations caused by the misincorporation of 8-oxoguanine into DNA. Here, we report that human cells have another mechanism for cleaning up the nucleotide pool to ensure accurate DNA replication. The human...

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Source

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Identifiers

PMID: 12717453
DOI: 10.1038/sj.embor.embor838
PMCID: PMC1319193

Genes

NUDT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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