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Article

Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity.

Nucleic acids research - 29 Oct 2014

Gordon Alasdair J E, Satory Dominik, Wang Mengyu, Halliday Jennifer A, Golding Ido, Herman Christophe

Abstract excerpt

Living in an oxygen-rich environment is dangerous for a cell. Reactive oxygen species can damage DNA, RNA, protein and lipids. The MutT protein in Escherichia coli removes 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) from the nucleotide pools precluding incorporation into DNA and RNA. While 8-oxo-dGTP incorporation into DNA is mutagenic, it is not clear if 8-oxo-GTP...

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Identifiers

PMID: 25294823
DOI: 10.1093/nar/gku912
PMCID: PMC4231768

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