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Article

A variant of DNA polymerase beta acts as a dominant negative mutant.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997

Bhattacharyya N, Banerjee S

Abstract excerpt

In eukaryotic cells, DNA polymerase beta (polbeta) carries out base-excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. A specific deletion in one allele in the coding sequence of the polbeta gene occurs in colorectal and breast carcinomas. The 87-bp deleted region encodes amino acid residues 208-236 in the catalytic domain of the enzyme. Here, we report evidence...

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Identifiers

PMID: 9294209
DOI: 10.1073/pnas.94.19.10324
PMCID: PMC23361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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