Article
Is there a link between DNA polymerase beta and cancer?
Cell cycle (Georgetown, Tex.) - 1 Aug 2004
Starcevic Daniela, Dalal Shibani, Sweasy Joann B
Abstract excerpt
Recent small-scale studies have shown that 30% of human tumors examined to date express DNA polymerase beta variant proteins. One of the DNA polymerase beta colon cancer-associated mutants, K289M, has been shown to synthesize DNA with a lower fidelity than wild-type Pol beta. Thus, the K289M protein could confer a mutator phenotype to the cell, resulting in genomic instability. Another DNA polymerase beta variant...
Topics
- Amino Acid Substitution
- Animals
- DNA Polymerase beta
- Genetic Variation
- Humans
- Neoplasms