Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of DNA polymerase results in an increased rate of frameshift mutations during base excision repair

31 Jan 2007

Abstract excerpt

DNA polymerase beta (Pol beta) is important for the base excision repair (BER) pathway. Overexpression of Pol beta is frequently found in cancer cells and is thought to be associated with tumorigenesis. In this study, we examined BER fidelity in extracts derived from a human lymphoblastoid cell line that over expresses Pol beta compared to normal control cells. Using an in vitro mutagenesis assay, we found an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17267816
DOI: 10.1093/mutage/gel070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of DNA polymerase results in an increased rate of frameshift mutations during base excision repairPMID 17267816Read ↗

Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs.Semantic proximity Read ↗

Overexpression of DNA polymerase β: a genomic instability enhancer processSemantic proximity Read ↗

A role for DNA polymerase beta in mutagenic UV lesion bypass.Semantic proximity Read ↗

Upregulation of Error-Prone DNA Polymerases Beta and Kappa Slows Down Fork Progression Without Activating the Replication CheckpointSemantic proximity Read ↗

DNA polymerase beta imbalance increases apoptosis and mutagenesis induced by oxidative stress.Semantic proximity Read ↗

Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities.Semantic proximity Read ↗

A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.Semantic proximity Read ↗

DNA polymerase expression differences in selected human tumors and cell linesSemantic proximity Read ↗

A variant of DNA polymerase beta acts as a dominant negative mutant.Semantic proximity Read ↗

Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.Semantic proximity Read ↗

Elevated expression of DNA polymerase II increases spontaneous mutagenesis in Escherichia coli.Semantic proximity Read ↗

Is there a link between DNA polymerase beta and cancer?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.