Article
DNA polymerase beta mutations in human colorectal cancer.
Cancer research - 1 Sept 1992
Wang L, Patel U, Ghosh L, Banerjee S
Abstract excerpt
Increasing numbers of alterations have been found in protooncogenes (e.g., ras, myc), as well as tumor suppressor genes (e.g., p53, Rb) in various types of tumors. The multiple mutations cannot be explained by the spontaneous mutation rate. It has been suggested that mutator phenotypes leading to the accumulation of these mutations may be required in the early stages of tumorigenesis. To test this hypothesis, the...
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