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Article

Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

Nucleic acids research - 1 Jun 2009

Guo Zhigang, Zheng Li, Dai Huifang, Zhou Mian, Xu Hong, Shen Binghui

Abstract excerpt

DNA polymerase beta (Pol beta) is a key enzyme in DNA base excision repair, and an important factor for maintaining genome integrity and stability. More than 30% of human tumors characterized to date express DNA Pol beta variants, many of which result from a single nucleotide residue substitution. However, in most cases, their precise functional deficiency and relationship to cancer susceptibility are still...

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Identifiers

PMID: 19336415
DOI: 10.1093/nar/gkp201
PMCID: PMC2691839

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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