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Article

A variant of DNA polymerase beta is not cancer specific.

Journal of investigative surgery : the official journal of the Academy of Surgical Research - 1 Jan 2000

Bu Dawei, Cler Leslie R, Lewis Cheryl M, Euhus David M

Abstract excerpt

DNA polymerase beta (pol beta) carries out base-excision repair (BER) required for DNA maintenance, replication, and recombination in eukaryotic cells. A variant characterized by a deletion of exon 11, an 87-bp region in the catalytic domain (pol betadelta208-236), was previously described as a possible cause of genomic instability in cancer. The variant form was hypothesized to act in a dominant negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15764500
DOI: 10.1080/08941930490524372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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