Article
Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice.
DNA repair - 13 May 2003
Sobol Robert W, Foley Julie F, Nyska Abraham, Davidson Michael G, Wilson Samuel H
Abstract excerpt
Base excision repair (BER) is a tightly coordinated mechanism for repair of DNA base damage (via alkylation and oxidation) and base loss. From E. coli to yeast to human cells, subtle alterations in expression of BER proteins lead to mutagenic or genome instability phenotypes. DNA polymerase beta (beta-pol), the major BER polymerase, has been found to be over-expressed in human tumor tissues and more recently it...
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