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Article

'Knock down' of DNA polymerase beta by RNA interference: recapitulation of null phenotype.

DNA repair - 2 Nov 2004

Polosina Yaroslava Y, Rosenquist Thomas A, Grollman Arthur P, Miller Holly

Abstract excerpt

DNA polymerase beta (pol beta) is the major DNA polymerase involved in the base excision repair (BER) pathway in mammalian cells and, as a consequence, BER is severely compromised in cells lacking pol beta. Pol beta null (-/-) mouse embryos are not viable and pol beta null cells are hypersensitive to alkylating agents. Using RNA interference (RNAi) technology in mouse cells, we have reduced the pol beta protein...

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Identifiers

PMID: 15380102
DOI: 10.1016/j.dnarep.2004.05.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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