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Article

A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.

PLoS genetics - 1 Jan 2012

Yamtich Jennifer, Nemec Antonia A, Keh Agnes, Sweasy Joann B

Abstract excerpt

Several germline single nucleotide polymorphisms (SNPs) have been identified in the POLB gene, but little is known about their cellular and biochemical impact. DNA Polymerase β (Pol β), encoded by the POLB gene, is the main gap-filling polymerase involved in base excision repair (BER), a pathway that protects the genome from the consequences of oxidative DNA damage. In this study we tested the hypothesis that...

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Source

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Identifiers

PMID: 23144635
DOI: 10.1371/journal.pgen.1003052
PMCID: PMC3493456

Genes

POLB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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