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Article

Is There a Link Between DNA Polymerase Beta and Cancer?

21 Aug 2004

Abstract excerpt

Recent small-scale studies have shown that 30% of human tumors examined to date express DNA polymerase beta variant proteins. One of the DNA polymerase beta colon cancer-associated mutants, K289M, has been shown to synthesize DNA with a lower fidelity than wild-type Pol beta. Thus, the K289M protein could confer a mutator phenotype to the cell, resulting in genomic instability. Another DNA polymerase beta variant...

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PMID: 15254423
DOI: 10.4161/cc.3.8.1062

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