Article
Human POLB gene is mutated in high percentage of colorectal tumors.
The Journal of biological chemistry - 6 Jul 2012
Donigan Katherine A, Sun Ka-wai, Nemec Antonia A, Murphy Drew L, Cong Xiangyu, Northrup Veronika, Zelterman Daniel, Sweasy Joann B
Abstract excerpt
Previous small scale sequencing studies have indicated that DNA polymerase β (pol β) variants are present on average in 30% of human tumors of varying tissue origin. Many of these variants have been shown to have aberrant enzyme function in vitro and to induce cellular transformation and/or genomic instability in vivo, suggesting that their presence is associated with tumorigenesis or its progression. In this...
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