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Article

Heparan Sulfate Biosynthesis in Zebrafish.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Jan 2021

Filipek-Górniok Beata, Habicher Judith, Ledin Johan, Kjellén Lena

Abstract excerpt

The biosynthesis of heparan sulfate (HS) proteoglycans occurs in the Golgi compartment of cells and will determine the sulfation pattern of HS chains, which in turn will have a large impact on the biological activity of the proteoglycans. Earlier studies in mice have demonstrated the importance of HS for embryonic development. In this review, the enzymes participating in zebrafish HS biosynthesis, along with a...

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Identifiers

PMID: 33216642
DOI: 10.1369/0022155420973980
PMCID: PMC7780192

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