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Article

QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling.

The Journal of cell biology - 21 Jul 2003

Ai Xingbin, Do Anh-Tri, Lozynska Olga, Kusche-Gullberg Marion, Lindahl Ulf, Emerson Charles P

Abstract excerpt

The 6-O sulfation states of cell surface heparan sulfate proteoglycans (HSPGs) are dynamically regulated to control the growth and specification of embryonic progenitor lineages. However, mechanisms for regulation of HSPG sulfation have been unknown. Here, we report on the biochemical and Wnt signaling activities of QSulf1, a novel cell surface sulfatase. Biochemical studies establish that QSulf1 is a heparan...

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Identifiers

PMID: 12860968
DOI: 10.1083/jcb.200212083
PMCID: PMC2172803

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Source receipt: pubmed, retrieved 7 Sept 2026.

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