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Article

Virulence plasmid instability in Shigella flexneri 2a is induced by virulence gene expression.

Infection and immunity - 1 Sept 1997

Schuch R, Maurelli A T

Abstract excerpt

Expression of the predominantly plasmid-encoded virulence regulon of Shigella flexneri 2a is induced by growth at 37 degrees C and repressed by growth at 30 degrees C. During growth at 37 degrees C, spontaneous S. flexneri mutants arise which have undergone virulence plasmid curing or rearrangement and no longer display the virulent phenotype. In the laboratory, the unstable nature of the virulence plasmid causes...

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Identifiers

PMID: 9284138
DOI: 10.1128/iai.65.9.3686-3692.1997
PMCID: PMC175525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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