Article
DNA supercoiling and environmental regulation of virulence gene expression in Shigella flexneri.
Nature - 19 Apr 1990
Dorman C J, Ni Bhriain N, Higgins C F
Abstract excerpt
Bacterial pathogens undergo profound physiological changes when they infect their hosts, requiring coordinated regulation of gene expression in response to the stresses encountered during infection. A number of environmental stresses (such as osmotic shock and anaerobiosis) have been shown to ind...
Topics
- DNA, Bacterial
- DNA, Recombinant
- DNA, Superhelical
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Mutation
- Phenotype
- Plasmids
- Shigella flexneri
- Temperature
- Transduction, Genetic
- Virulence