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Article

DNA supercoiling and environmental regulation of virulence gene expression in Shigella flexneri.

Nature - 19 Apr 1990

Dorman C J, Ni Bhriain N, Higgins C F

Abstract excerpt

Bacterial pathogens undergo profound physiological changes when they infect their hosts, requiring coordinated regulation of gene expression in response to the stresses encountered during infection. A number of environmental stresses (such as osmotic shock and anaerobiosis) have been shown to induce changes in DNA supercoiling that can directly affect the transcription of a specific subset of bacterial genes, at...

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PMID: 2184366
DOI: 10.1038/344789a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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