Article

The role of toxin:antitoxin systems and insertion sequences in the loss of virulence in <i>Shigella sonnei</i>

2020-08-10

Abstract excerpt

<h4>SUMMARY</h4> The Shigella plasmid, pINV, contains a 30 kb pathogenicity island (PAI) encoding a Type III secretion system (T3SS) which is essential for virulence. During growth in the laboratory, avirulent colonies of Shigella (which do not express a T3SS) arise spontaneously. Avirulence in Shigella flexneri mostly follows loss of the PAI, following recombination between insertion sequences (ISs) on pINV;...

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Literature Corpus work: a7602d17-ed02-5e99-af81-11a8d926033f
DOI: 10.1101/2020.08.10.243006

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