Loss of heterozygosity of a locus in the chromosomal region 17p13.3 is associated with increased cell proliferation in astrocytic tumors.

doi:10.1016/s0165-4608(02)00937-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Loss of heterozygosity of a locus in the chromosomal region 17p13.3 is associated with increased cell proliferation in astrocytic tumors.

Cancer genetics and cytogenetics - 15 Jul 2003

Sarkar Chitra, Chattopadhyay Parthaprasad, Ralte Angela Mercy, Mahapatra Ashok K, Sinha Subrata

Abstract excerpt

We had previously reported that loss of heterozygosity (LOH) of the D17S379 locus on 17p13.3 was significantly more frequent in high-grade gliomas (anaplastic astrocytoma, AA; glioblastoma multiforme, GBM) than in those of a low-grade diffuse astrocytoma (DA); however, this was independent of alterations at the TP53 locus, We also showed that LOH of D17S379 was associated with positive staining for p53 protein on...

Topics

Adult
Age Factors
Astrocytoma
Cell Division
Chromosomes, Human, Pair 17
Genes, p53
Humans
Ki-67 Antigen
Loss of Heterozygosity
Middle Aged
Mutation

Source

Open in PubMed

Identifiers

PMID: 12850379
DOI: 10.1016/s0165-4608(02)00937-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics