Article
Molecular pathogenesis of malignant gliomas.
Current opinion in oncology - 1 May 1999
Rasheed B K, Wiltshire R N, Bigner S H, Bigner D D
Abstract excerpt
De novo glioblastomas develop in older patients without prior clinical history of less malignant tumors. Progressive glioblastomas are common among younger patients and arise through progression from lower-grade astrocytomas. CDKN2A deletions, PTEN alterations, and EGFR amplification are more prevalent among de novo glioblastomas, whereas p53 mutations are more common among progressive glioblastomas. Loss of...
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