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Article

Generation of novel human MHC class II mutant B-cell lines by integrating YAC DNA into a cell line homozygously deleted for the MHC class II region.

Human molecular genetics - 1 Aug 1997

Fabb S A, Davies A F, Correa I, Kelly A P, Mackie C, Trowsdale J, Ragoussis J

Abstract excerpt

The human B lymphoblastoid cell line (LCL) 721.174 sustains a large homozygous deletion in the major histocompatibility complex (MHC) class II region that results in an absence of DQ and DR molecules as well as a deficiency in the assembly and transport of class I molecules to the cell surface. The deleted genes include the transporters associated with antigen processing TAP1 and TAP2, DMA and DMB which are...

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Source

Identifiers

PMID: 9259276
DOI: 10.1093/hmg/6.8.1295

Genes

TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Generation of novel human MHC class II mutant B-cell lines by integrating YAC DNA into a cell line homozygously deleted for the MHC class II region.PMID 9259276Read ↗

Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DNA in the class II region of the MHC.Semantic proximity Read ↗

MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.Semantic proximity Read ↗

Genetic complexity of regulatory mutants defective for HLA class II gene expression.Semantic proximity Read ↗

Expression of HLA class I antigens in transporter associated with antigen processing (TAP)-deficient mutant cell lines.Semantic proximity Read ↗

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line.Semantic proximity Read ↗

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.Semantic proximity Read ↗

Impaired antigen presentation by murine I-Ad class II MHC molecules expressed in normal and HLA-DM-defective human B cell lines.Semantic proximity Read ↗

Analysis of HLA-DMB mutants and -DMB genomic structure.Semantic proximity Read ↗

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.Semantic proximity Read ↗

Large transcripts and sequence from a polymorphic 170 kb MHC region implicated in susceptibility to autoimmune disease.Semantic proximity Read ↗

HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.Semantic proximity Read ↗

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