Article
Large transcripts and sequence from a polymorphic 170 kb MHC region implicated in susceptibility to autoimmune disease.
Immunogenetics - 1 Jan 1994
Marshall B, Leelayuwat C, Abraham L J, Pinelli M, Dawkins R L
Abstract excerpt
We have used the novel strategy of overlapping yeast artificial chromosome (YAC) clones to localize a series of new transcripts within a 170 kb region of the human major histocompatibility complex (MHC), containing genes likely to be of importance for disease susceptibility. Using cloned genomic...
Topics
- Autoimmune Diseases
- Blotting, Northern
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Gene Library
- Genetic Predisposition to Disease
- Humans
- Introns
- Liver
- Lung
- Major Histocompatibility Complex
- Polymorphism, Genetic
- RNA
- Transcription, Genetic