Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translational misreading: mutations in translation elongation factor 1alpha differentially affect programmed ribosomal frameshifting and drug sensitivity.

RNA (New York, N.Y.) - 1 Aug 1997

Dinman J D, Kinzy T G

Abstract excerpt

The translation elongation feactor 1alpha (EF-1alpha) catalyzes the critical step of delivering aminoacyl-tRNAs to the elongating ribosome. A series of Saccharomyces cerevisiae strains containing mutant alleles of the TEF2 gene encoding EF-1alpha have phenotypes consistent with effects on cellular processes related to translation. These include (1) conditional growth defects, (2) antibiotic sensitivity or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutation

Share to Protein Biosynthesis

Share to RNA, Messenger

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9257646
PMCID: PMC1369532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translational misreading: mutations in translation elongation factor 1alpha differentially affect programmed ribosomal frameshifting and drug sensitivity.PMID 9257646Read ↗

Effect of frameshift-inducing mutants of elongation factor 1alpha on programmed +1 frameshifting in yeast.Semantic proximity Read ↗

Increased expression of Saccharomyces cerevisiae translation elongation factor 1 alpha bypasses the lethality of a TEF5 null allele encoding elongation factor 1 beta.Semantic proximity Read ↗

The Mof2/Sui1 protein is a general monitor of translational accuracy.Semantic proximity Read ↗

Near-cognate peptidyl-tRNAs promote +1 programmed translational frameshifting in yeast.Semantic proximity Read ↗

New targets for antivirals: the ribosomal A-site and the factors that interact with it.Semantic proximity Read ↗

Identification of a cellular factor that modulates HIV-1 programmed ribosomal frameshifting.Semantic proximity Read ↗

Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies.Semantic proximity Read ↗

Mutations in elongation factor 1beta, a guanine nucleotide exchange factor, enhance translational fidelity.Semantic proximity Read ↗

Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae.Semantic proximity Read ↗

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.Semantic proximity Read ↗

Distinct response of yeast ribosomes to a miscoding event during translation.Semantic proximity Read ↗

tRNA hopping: effects of mutant tRNAs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.