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Article

Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies.

Genetics - 1 Jan 1994

Dinman J D, Wickner R B

Abstract excerpt

A special site on the (+) strand of the L-A dsRNA virus induces about 2% of ribosomes translating the gag open reading frame to execute a -1 frameshift and thus produce the viral gag-pol fusion protein. Using constructs in which a -1 ribosomal frameshift at this site was necessary for expression of lacZ we isolated chromosomal mutants in which the efficiency of frameshifting was increased. These mutants comprise...

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Identifiers

PMID: 8138178
DOI: 10.1093/genetics/136.1.75
PMCID: PMC1205794

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