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Article

New targets for antivirals: the ribosomal A-site and the factors that interact with it.

Virology - 15 Aug 2002

Goss Kinzy Terri, Harger Jason W, Carr-Schmid Anne, Kwon Jane, Shastry Mythili, Justice Michael, Dinman Jonathan D

Abstract excerpt

Many viruses use programmed -1 ribosomal frameshifting to ensure the correct ratio of viral structural to enzymatic proteins. Alteration of frameshift efficiencies changes these ratios, in turn inhibiting viral particle assembly and virus propagation. Previous studies determined that anisomycin, a peptidyl transferase inhibitor, specifically inhibited -1 frameshifting and the ability of yeast cells to propagate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12202206
DOI: 10.1006/viro.2002.1567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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