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Article

Near-cognate peptidyl-tRNAs promote +1 programmed translational frameshifting in yeast.

Molecular cell - 1 Dec 1999

Sundararajan A, Michaud W A, Qian Q, Stahl G, Farabaugh P J

Abstract excerpt

Translational frameshifting is a ubiquitous, if rare, form of alternative decoding in which ribosomes spontaneously shift reading frames during translation elongation. In studying +1 frameshifting in Ty retrotransposons of the yeast S. cerevisiae, we previously showed that unusual P site tRNAs induce frameshifting. The frameshift-inducing tRNAs we show here are near-cognates for the P site codon. Their abnormal...

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PMID: 10635325
DOI: 10.1016/s1097-2765(00)80229-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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