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Article

Double Holliday junctions are intermediates of DNA break repair.

Nature - 8 Apr 2010

Bzymek Malgorzata, Thayer Nathaniel H, Oh Steve D, Kleckner Nancy, Hunter Neil

Abstract excerpt

Repair of DNA double-strand breaks (DSBs) by homologous recombination is crucial for cell proliferation and tumour suppression. However, despite its importance, the molecular intermediates of mitotic DSB repair remain undefined. The double Holliday junction (DHJ), presupposed to be the central intermediate for more than 25 years, has only been identified during meiotic recombination. Moreover, evidence has...

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Identifiers

PMID: 20348905
DOI: 10.1038/nature08868
PMCID: PMC2851831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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