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Article

Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity.

Genetics - 1 Nov 2015

O'Connell Karen, Jinks-Robertson Sue, Petes Thomas D

Abstract excerpt

Two types of RNA:DNA associations can lead to genome instability: the formation of R-loops during transcription and the incorporation of ribonucleotide monophosphates (rNMPs) into DNA during replication. Both ribonuclease (RNase) H1 and RNase H2 degrade the RNA component of R-loops, whereas only RNase H2 can remove one or a few rNMPs from DNA. We performed high-resolution mapping of mitotic recombination events...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26400613
DOI: 10.1534/genetics.115.182725
PMCID: PMC4649664

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Source receipt: pubmed, retrieved 7 Sept 2026.

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