The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.

doi:10.1038/nsmb.2359

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Article

The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.

Nature structural & molecular biology - 1 Sept 2012

Mazón Gerard, Lam Alicia F, Ho Chu Kwen, Kupiec Martin, Symington Lorraine S

Abstract excerpt

Holliday junctions can be formed during homology-dependent repair of DNA double-strand breaks, and their resolution is essential for chromosome segregation and generation of crossover products. The Mus81-Mms4 and Yen1 nucleases are required for mitotic crossovers between chromosome homologs in Saccharomyces cerevisiae; however, crossovers between dispersed repeats are still detected in their absence. Here we show...

Topics

Chromosomes, Fungal
DNA Repair Enzymes
DNA-Binding Proteins
Endonucleases
Holliday Junction Resolvases
Mutation
Plasmids
Recombination, Genetic
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Single-Strand Specific DNA and RNA Endonucleases

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Identifiers

PMID: 22885325
DOI: 10.1038/nsmb.2359
PMCID: PMC3443319

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