Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates.

Molecular cell - 10 Oct 2013

Mazón Gerard, Symington Lorraine S

Abstract excerpt

Homology-dependent repair of double-strand breaks (DSBs) from nonsister templates has the potential to generate loss of heterozygosity or genome rearrangements. Here we show that the Saccharomyces cerevisiae Mph1 helicase prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage. A role for Yen1 is only apparent in the absence of Mus81. Cells lacking Mph1 and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to DNA Breaks, Double-Stranded
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endonucleases

Share to Flap Endonucleases

Share to Mitosis

Share to RecQ Helicases

Share to Single-Strand Specific DNA and RNA Endonucleases

Source

Open in PubMed Open full text

Identifiers

PMID: 24119400
DOI: 10.1016/j.molcel.2013.09.007
PMCID: PMC3818723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates.PMID 24119400Read ↗

The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.Semantic proximity Read ↗

Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Semantic proximity Read ↗

Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repair.Semantic proximity Read ↗

Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.Semantic proximity Read ↗

RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Semantic proximity Read ↗

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.Semantic proximity Read ↗

BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism.Semantic proximity Read ↗

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Semantic proximity Read ↗

Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

<i>mlh3</i> separation of function and endonuclease defective mutants display an unexpected effect on meiotic recombination outcomesSemantic proximity Read ↗

Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans.Semantic proximity Read ↗

Processing of homologous recombination repair intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.