DNA repeat rearrangements mediated by DnaK-dependent replication fork repair.

doi:10.1016/j.molcel.2006.01.025

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Article

DNA repeat rearrangements mediated by DnaK-dependent replication fork repair.

Molecular cell - 3 Mar 2006

Goldfless Stephen J, Morag Aviv Segal, Belisle Kurt A, Sutera Vincent A, Lovett Susan T

Abstract excerpt

We propose that rearrangements between short tandem repeated sequences occur by errors made during a replication fork repair pathway involving a replication template switch. We provide evidence here that the DnaK chaperone of E. coli controls this template switch repair process. Mutants in dnaK are sensitive to replication fork damage and exhibit high expression of the SOS response, indicative of repair...

Topics

DNA Polymerase III
DNA Repair
DNA Replication
DNA, Bacterial
Escherichia coli
Escherichia coli Proteins
Gene Rearrangement
HSP70 Heat-Shock Proteins
Mutation
Rec A Recombinases
Recombination, Genetic
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 16507358
DOI: 10.1016/j.molcel.2006.01.025

Genes

RAD18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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