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Article

Exceptional origin activation revealed by comparative analysis in two laboratory yeast strains.

PloS one - 1 Jan 2022

Joshi Ishita, Peng Jie, Alvino Gina, Kwan Elizabeth, Feng Wenyi

Abstract excerpt

We performed a comparative analysis of replication origin activation by genome-wide single-stranded DNA mapping in two yeast strains challenged by hydroxyurea, an inhibitor of the ribonucleotide reductase. We gained understanding of the impact on origin activation by three factors: S-phase checkpoint control, DNA sequence polymorphisms, and relative positioning of origin and transcription unit. Wild type W303...

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Identifiers

PMID: 35157703
DOI: 10.1371/journal.pone.0263569
PMCID: PMC8843211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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