Article
Sensitivity of transformed fibroblasts for intercellular induction of apoptosis is determined by their transformed phenotype.
Experimental cell research - 10 Jul 1997
Beck E, Schäfer R, Bauer G
Abstract excerpt
Intercellular induction of apoptosis defines a potential control mechanism of oncogenesis. It is based on induction of apoptosis in transformed fibroblasts by neighboring nontransformed fibroblasts. Transforming growth factor type beta (TGF-beta) represents the initial triggering molecule to induce nontransformed cells to release apoptosis-inducing factors. To test whether sensitivity for intercellular induction...
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