Reversion by deletion of transforming oncogene following interferon-beta and retinoic acid treatment.

doi:10.1089/jir.1997.17.647

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Reversion by deletion of transforming oncogene following interferon-beta and retinoic acid treatment.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Oct 1997

Friedman R M, Yeh A, Gutman P, Contente S, Kenyon K

Abstract excerpt

We have previously shown that prolonged interferon-beta (IFN-beta) treatment of RS485 cells (NIH3T3 cells transformed with multiple copies of an LTR-cHa-ras oncogene) resulted in the phenotypic reversion of 1%-5% of the culture, depending on the conditions used. This reversion persisted after IFN-beta was discontinued, although the revertants retained the LTR-cHa-ras and continued to express ras mRNA and p21....

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PMID: 9355967
DOI: 10.1089/jir.1997.17.647

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