Intercellular induction of apoptosis through modulation of endogenous survival factor concentration: a review.

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Article

Intercellular induction of apoptosis through modulation of endogenous survival factor concentration: a review.

Anticancer research - 1 Jan 2000

Dormann S, Schwieger A, Hanusch J, Häufel T, Engelmann I, Bauer G

Abstract excerpt

Fibroblasts constitutively express a functional apoptosis machinery which is under negative control by operationally defined endogenous survival factors. Oncogenic transformation causes a marked downmodulation of endogenous survival factor concentration which renders transformed cells more sensitive to various apoptosis stimuli compared to their nontransformed counterparts. Endogenous survival factors can be...

Topics

Animals
Apoptosis
Cell Communication
Cell Survival
Cell Transformation, Neoplastic
Genes, p53
Humans
Phenotype
Reactive Oxygen Species
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 10226529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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