Article
Intercellular induction of apoptosis through modulation of endogenous survival factor concentration: a review.
Anticancer research - 1 Jan 2000
Dormann S, Schwieger A, Hanusch J, Häufel T, Engelmann I, Bauer G
Abstract excerpt
Fibroblasts constitutively express a functional apoptosis machinery which is under negative control by operationally defined endogenous survival factors. Oncogenic transformation causes a marked downmodulation of endogenous survival factor concentration which renders transformed cells more sensitive to various apoptosis stimuli compared to their nontransformed counterparts. Endogenous survival factors can be...
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