Cell transforming genes and tumor progression: in vivo unified secondary phenotypic cell changes.

doi:10.1002/(sici)1097-0215(19980119)75:2<277::aid-ijc17>3.0.co;2-a

Back to search

Article

Cell transforming genes and tumor progression: in vivo unified secondary phenotypic cell changes.

International journal of cancer - 19 Jan 1998

Deichman G J, Matveeva V A, Kashkina L M, Dyakova N A, Uvarova E N, Nikiforov M A, Gudkov A V

Abstract excerpt

We have earlier shown that Syrian hamster cells spontaneously transformed in vitro during in vivo progression, acquire in 1 step, along with highly increased tumorigenicity, 2 new properties characterizing the [H2O2CA + tPGE(S)] phenotype, i.e., a high H2O2 catabolizing (antioxidant) activity and...

Topics

Animals
Cell Transformation, Neoplastic
Cricetinae
Genes, bcl-2
Mesocricetus
Neoplasms, Experimental
Oncogenes
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.